[Results] 26 weeks, 5kg, and dose escalation was the hard part
26 weeks, 5kg, and dose escalation was the hard part. Same spreadsheet I have been keeping since the start, nothing retrofitted. Figures up front so nobody has to dig: 26 weeks and 5kg. Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with…
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
Is that the 48-week figure or an earlier readout?
the energy-expenditure story is mechanistically interesting and clinically unproven
small trial, big effect, wide error bars
Kept a log specifically because there is so little published. It is one person and it is not data.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.