someone explain phase 2 to me like I have not read a paper in years
Genuine question, and the title is the question: someone explain phase 2 to me like I have not read a paper in years. Stopped at a low step because there was no reason to go further and no data to tell me what further would do. The thing that surprised me was how much of the discussion here is inference rather than…
Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.
the escalation is where most of the reported trouble sits
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
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Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.
the phase 2 numbers were striking and they were also 48 weeks in a small population
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.