[Caution] "just start at 2mg" is the worst advice in this community
"just start at 2mg" is the worst advice in this community, which sounds obvious until you try to state the evidence for it.
Pulling the figures out of the title: 2mg. All of it is written down as it happened rather than reconstructed.
Where the evidence actually stands, since every thread here assumes a different answer.
Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.
Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.
Stopped at a low step because there was no reason to go further and no data to tell me what further would do.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
Has anyone posted an independent test on this compound recently?
Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part.
Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.
Standing note on this board: unapproved compound, phase 2 data, and no titration plans for other members. That is the whole ruleset.
That is body weight change, not fat mass. The trials report the first and people quote it as the second.
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
wait for phase 3 before you argue about rankings
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.