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c/retatrutide·submitted 11 months ago by u/anya_moreau

[Results] 8 weeks on 7.5mg, full numbers, ask me anything boring

Resultsbranch of 6 comments

Six-word version is the title — 8 weeks on 7.5mg, full numbers, ask me anything boring — and the rest is context. Hard numbers: 8 weeks and 7.5mg. Anything softer than that is flagged as an impression. The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the…

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6 comments, started 11 months ago
u/ismael_eriksen313 points·11 months ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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u/yusuf_ramos70 points·11 months ago

How fast was the escalation? That is usually the variable that explains the reports.

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[removed]50 points·11 months ago

[removed by moderator]

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u/rohan_cardoso18 points·11 months ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/anya_moreauOP13 points·11 months ago

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/injection_site_iris5 points·11 months ago·edited

nothing here is available as a prescription product, so read every thread with that in mind

rohan_cardoso is right about the escalation being the variable. It explains most of the difficult reports here.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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