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c/retatrutide·posted 1 months ago by u/hassan_nilsen

anyone else notice retatrutide kicking in around week 83

Caution Clean Column ×1 Slow Clap ×3

Reporting in. anyone else notice retatrutide kicking in around week 83.

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.

The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.

Happy to answer the boring questions. Those are usually the ones worth asking.

1,963 up / 229 down90% upvoted19 commentsid 1vf5ac29 Jun 2026

19 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/endotoxin_elliemicro229 points·1 months ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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u/hassan_nilsenOP107 points·29 days ago

Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.

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u/hassan_nilsenOP60 points·29 days ago·edited

Is that the 48-week figure or an earlier readout?

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u/hassan_nilsenOP39 points·29 days ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/janek_ferrari169 points·1 months ago

wait for phase 3 before you argue about rankings

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u/customs_seizure_sid140 points·29 days ago

the glucagon component is why the metabolic story reads differently

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u/jarno_cabrera134 points·1 months ago

Has anyone posted an independent test on this compound recently?

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u/honest_syringe_202556 points·29 days ago

What is the source for that figure — the published paper or a summary of it?

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u/deleted_my_history34 points·29 days ago·edited

the escalation is where most of the reported trouble sits

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u/kofi_balogun71 points·29 days ago·edited

Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.

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u/two_mil_or_one42 points·29 days ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/aa_analysis_andy106 points·28 days ago

Not convinced. You are attributing a week of sulphur burps to the glucagon arm when the escalation rate alone would explain it.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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