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Single comment threadYou are looking at one branch of genuine question about TRIUMPH that I am slightly embarrassed to ask — 30 comments in the full submission. View in context.
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c/retatrutide·submitted 1 year ago by u/marit_laurent

genuine question about TRIUMPH that I am slightly embarrassed to ask

Labbranch of 7 comments

genuine question about TRIUMPH that I am slightly embarrassed to ask. I am not trying to be the "source?" guy. I would just like a source. Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish. Phase 2 estimates…

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7 comments, started 1 year ago
u/yannick_salinas257 points·1 year ago

Are you tracking heart rate at all?

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u/ismael_eriksen97 points·1 year ago

nothing here is available as a prescription product, so read every thread with that in mind

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u/mateusz_mensah26 points·1 year ago

What is the source for that figure — the published paper or a summary of it?

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u/marit_laurentOP-8 points·1 year ago

Is that the 48-week figure or an earlier readout?

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[deleted]36 points·1 year ago

[deleted]

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u/injection_site_iris9 points·1 year ago

heart rate is the thing people report watching

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u/devils_advocate_d7 points·1 year ago

Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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