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Single comment threadYou are looking at one branch of genuine question about TRIUMPH that I am slightly embarrassed to ask — 30 comments in the full submission. View in context.
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c/retatrutide·submitted 1 year ago by u/marit_laurent

genuine question about TRIUMPH that I am slightly embarrassed to ask

Labbranch of 9 comments

genuine question about TRIUMPH that I am slightly embarrassed to ask. I am not trying to be the "source?" guy. I would just like a source. Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish. Phase 2 estimates…

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9 comments, started 1 year ago
u/helga_vermeulen166 points·1 year ago

wait for phase 3 before you argue about rankings

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u/reta_and_regretMOD108 points·1 year ago

Removed the escalation schedule. There is no published protocol for members to follow and inventing one here is exactly what this board does not do.

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u/marit_laurentOP82 points·1 year ago

Removed the escalation schedule.

Agreed, and the glucagon arm is exactly why the comparison threads do not work.

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u/reta_and_regret24 points·1 year ago

dose escalation in the trials was slow for a reason

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u/farid_molnar67 points·1 year ago

a lot of the confident posting here is extrapolation

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u/tired_ledger_notes34 points·1 year ago

the TRIUMPH programme is still running, so anything definitive is premature

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u/trialwatch_theotrial nerd28 points·1 year ago

Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.

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u/bastian_ekstrom27 points·1 year ago

The sulphur burps profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

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u/janek_ferrari126 points·1 year ago

Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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