[Results] 45 weeks on 10mg, full numbers, ask me anything boring
45 weeks on 10mg, full numbers, ask me anything boring, and the part I actually want to talk about is at the bottom. Pulling the figures out of the title: 45 weeks and 10mg. All of it is written down as it happened rather than reconstructed. Nothing containing this compound is approved anywhere. Research-use-only…
The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.
Small fix — three receptors, not two. GLP-1, GIP and glucagon, and the third one is the reason this compound gets its own board.
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Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.
Correcting my own comment above: that figure was the 36-week interim, not the 48-week endpoint.
Disagree with this specific inference. A 48-week readout does not tell you the shape of the curve after it.
Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.
small trial, big effect, wide error bars