[Results] 66 weeks, 24kg, and triple agonist was the hard part
66 weeks, 24kg, and triple agonist was the hard part. Full detail below, and I have tried to keep the editorialising out of it.
Since the title puts numbers in the shop window: 66 weeks and 24kg.
Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.
Independent purity testing on this compound is thin compared with the older molecules, simply because fewer members have paid for it. Fewer results means wider uncertainty, not a verdict.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
Where the evidence actually stands, since every thread here assumes a different answer.
Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.
Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.
This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.
not approved anywhere, which is the single most important fact in this board
Agreed, and the framing that helps is: this is a phase 2 compound with phase 3 running. Everything else is inference.
Are you tracking heart rate at all?
What is the source for that figure — the published paper or a summary of it?
Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.
Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.