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c/retatrutide·submitted 2 years ago by u/discount_math_dm

is it normal to get sulphur burps at week 24

Discussionbranch of 8 comments

is it normal to get sulphur burps at week 24. Full detail below, and I have tried to keep the editorialising out of it. The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number. Glucagon receptor agonism is…

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8 comments, started 2 years ago
u/nabila_bakken282 points·2 years ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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[removed]105 points·2 years ago

[removed by moderator]

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u/discount_math_dmOP43 points·2 years ago

Is that the 48-week figure or an earlier readout?

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u/liver_enzyme_liz12 points·2 years ago

Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.

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u/hassan_nilsen-4 points·2 years ago

phase 2 data only, and people quote it like it is a label

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u/discount_math_dmOP1 point·2 years ago

phase 2 data only, and people quote it like it is a label

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

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u/endotoxin_elliemicro1 point·2 years ago·edited

Adding the standing caveat: none of this is approved anywhere and research material is not for human use.

This is the sentence the rest of the board should read first. Phase 2 is not a label.

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u/sofia_wikstrom1 point·2 years ago

Careful with the rankings. A phase 2 result and a phase 3 result are not on the same evidential footing and cannot be listed in one table.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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