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c/researchpeptides·submitted 2 years ago by u/marit_laurent

[Meta] the TB-500 rule is doing its job and people should stop complaining

Explainerbranch of 7 comments

the TB-500 rule is doing its job and people should stop complaining. Comments open, and the wording is genuinely up for discussion. Confirmed the lead time in writing before ordering a made-to-order line. It was longer than the site suggested and entirely reasonable once explained. Bought small on anything without a…

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7 comments, started 2 years ago
u/salma_almeida257 points·2 years ago·edited

Not convinced. A purity figure without a stated method is not comparable to one that has a method attached.

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u/georgi_adebayo63 points·2 years ago

Not convinced.

Disagreeing with this bit: handling for one compound does not transfer to another by default.

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u/tb500_tangent-31 points·2 years ago

Has anyone here tested that compound at all?

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u/old_account_20231 point·2 years ago

Agreed that thin testing here says something about the members, not about the material.

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u/marit_laurentOP36 points·2 years ago

That method was developed for a different compound class and would not resolve the impurities you are asking about.

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u/aa_analysis_andy60 points·2 years ago

For any compound with a thin testing history, identity is the first question. Mass spectrometry against a theoretical mass answers it; an area-percent purity figure does not.

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u/line_bergstrom17 points·2 years ago

Purity methods differ by compound class. A gradient and wavelength developed for one peptide will not necessarily resolve the relevant impurities of another.

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