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c/researchpeptides·submitted 1 year ago by u/due_diligence_dee

[PSA] TB-500 is not what most of this community thinks it is

Discussionbranch of 9 comments

The one-line version is the title: TB-500 is not what most of this community thinks it is. The rest is why. Storage conditions came back specific rather than generic when I asked. That told me somebody had actually done stability work. The three questions to ask before ordering anything from the long tail of a…

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9 comments, started 1 year ago
u/naomi_antonsen17 points·1 year ago

For any compound with a thin testing history, identity is the first question. Mass spectrometry against a theoretical mass answers it; an area-percent purity figure does not.

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u/hassan_ostergaard4 points·1 year ago

Purity methods differ by compound class. A gradient and wavelength developed for one peptide will not necessarily resolve the relevant impurities of another.

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u/formulary_fighterappeals3 points·1 year ago

Disagree — that name refers to at least two different molecules depending on who is selling it. The thread needs to be specific.

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u/due_diligence_deeOP2 points·1 year ago

a secretagogue and a fragment are not the same class of thing

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u/anya_moreau2 points·1 year ago

This. Asking what reference standard was used separates a real analytical claim from a plausible-looking one.

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u/old_account_20231 point·1 year ago

That method was developed for a different compound class and would not resolve the impurities you are asking about.

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u/adaeze_brandt5 points·1 year ago

the sequence is the product, everything else is packaging

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u/greta_lokken11 points·1 year ago

Small fix — that is net peptide content, not purity. Both are on the certificate and they differ substantially here.

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u/reverse_image_ron4 points·1 year ago

Cosigning the lead-time point. Made-to-order and stocked are completely different propositions and both are legitimate.

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