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c/reconstitution·submitted 2 years ago by u/sigrid_kaufmann

reading concentration threads from 2024 and half of it aged badly

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reading concentration threads from 2024 and half of it aged badly — a position I have arrived at slowly and would like tested. Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful. Reconstituted at…

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9 comments, started 2 years ago
u/bruno_dumitru111 points·2 years ago

bacteriostatic water has the preservative, sterile water does not

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u/georgi_adebayo0 points·2 years ago

What is written on the vial right now?

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u/andres_sorensen53 points·2 years ago

Yes. Writing 5mg/mL on the vial takes four seconds and removes the entire class of error this board exists to fix.

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u/katrin_marchetti12 points·2 years ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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u/emil_zamora3 points·2 years ago

Adding more water does not change how much peptide is in the vial. It changes the concentration, which changes the volume you draw for the same amount. That is the entire relationship.

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u/anjali_tamm2 points·2 years ago

more water is not more drug, it is the same drug in a bigger volume

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u/yusuf_nakamura68 points·2 years ago

Disagree with the "more water is safer" framing. It is not safer, it is just a different number to divide by.

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u/sigrid_kaufmannOP28 points·2 years ago

units are a volume on a U-100 syringe, not a dose

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u/india_generic_g42 points·2 years ago

Not quite. Bacteriostatic and sterile water are not interchangeable for a multi-draw vial, and the difference is the preservative.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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