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c/reconstitution·submitted 1 year ago by u/liv_nkemelu

someone explain insulin syringe to me like I have not read a paper in years

Discussionbranch of 7 comments

The title is the whole question — someone explain insulin syringe to me like I have not read a paper in years — but here is why I am asking. Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person. If your…

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7 comments, started 1 year ago
u/ilias_cabrera103 points·1 year ago·edited

The arithmetic in full: concentration is mass over volume, so 15mg into 3mL gives 5mg/mL. A U-100 syringe is graduated at 100 units per millilitre, so 1.5mg is 1.5 divided by 5 millilitres, which is 30 units.

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u/saskia_rahimi38 points·1 year ago

the number you write down is the number you will trust at 6am

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u/bruno_dumitru26 points·1 year ago

Disagree with the "more water is safer" framing. It is not safer, it is just a different number to divide by.

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u/swirl_dont_shakereconstitution14 points·1 year ago

Same. I got this wrong once, caught it because the units looked absurd, and have written on every vial since.

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u/elin_ferrari19 points·1 year ago·edited

the number you write down is the number you will trust at 6am

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

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u/arto_falk45 points·1 year ago

Asked WXT what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know.

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u/liv_nkemeluOP0 points·1 year ago

Small fix — a U-100 syringe is 100 units per mL. If yours is marked differently it is not U-100 and the whole calculation changes.

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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