[Discussion] the ACHIEVE advice in here is 3 years out of date
Thinking out loud about this: the ACHIEVE advice in here is 3 years out of date. 3 years — those are the numbers, and they are the ones I am willing to defend. Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use. Assumed the peptide purity…
Corrected a cross-class dose comparison in the title. The body is untouched.
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
do not assume reconstitution intuitions apply, there is nothing to reconstitute
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.
Is that from the publication or the press release?
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
jonas_cardoso is right that milligram comparisons across classes tell you nothing.
jonas_cardoso is right that milligram comparisons across classes tell you nothing.
Adding the standing caveat — unapproved, and research material is not for human use.
Cosigning on daily dosing. It changes the exposure profile and it changes adherence, in both directions.
oral semaglutide is a peptide with an absorption enhancer, this is not that
phase 3 is where the comparison becomes fair
phase 3 is where the comparison becomes fair
This is the fact the whole board hangs on. Small molecule, not peptide.
small molecule, not a peptide, and that changes everything about it