reading ATTAIN threads from 2024 and half of it aged badly
Posting this as a discussion rather than a claim: reading ATTAIN threads from 2024 and half of it aged badly. Milligram comparisons across molecule classes are meaningless. Potency is a property of the molecule at its receptor, not of the number on the label. Daily dosing gives a very different exposure profile from…
Standing reminder: unapproved compound, research material is not for human use, and no schedules for other members.
Phase 2 or phase 3?
Milligram-for-milligram comparison with an injectable peptide is not meaningful and I should not have made it.
the tolerability profile reads broadly similar to the class
Standing reminder: unapproved compound, research material is not for human use, and no schedules for other members.
trialwatch_theo is right that milligram comparisons across classes tell you nothing.
do not assume reconstitution intuitions apply, there is nothing to reconstitute
do not assume reconstitution intuitions apply, there is nothing to reconstitute
Agreed, and it is why the oral peptide comparison keeps misleading people.
Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.
This. The absence of food and water timing restrictions is the practical difference people will actually notice.
Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.