the gastric emptying thing finally clicked for me and I want to write it down
the gastric emptying thing finally clicked for me and I want to write it down. Change my mind, genuinely — I have no stake in being right about this. Tried to build a mental model from mechanism alone and produced a confident prediction that the trial data flatly contradicted. Spent an evening on the receptor…
Yes. The discussion section is where the authors say what they actually think, and almost nobody here reads it.
Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board reports.
Is there any human data on that mechanism yet?
glucagon agonism sounds paradoxical until you read the energy expenditure work
Are we talking about receptor affinity or clinical potency?
That study was in a rodent model. Worth stating, since the thread has been reading it as human data.