[Discussion] can we stop arguing about appetite until somebody posts a number
Question in the title, detail here: can we stop arguing about appetite until somebody posts a number. The incretin effect is the observation that oral glucose provokes a larger insulin response than intravenous glucose at matched glycaemia, and the difference is mediated by gut hormones. That is the foundation the…
Left up and flaired Explainer. This is the standard of post the board was created for.
a mechanism you can state is not a mechanism you have demonstrated
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.
Correction: that is glucose-dependent insulin secretion, which is why hypoglycaemia risk is low as monotherapy. Not the same claim as you made.
Went looking for human data on a mechanism everybody here asserts. Found preclinical work and one small study. That was clarifying.
Yes. The discussion section is where the authors say what they actually think, and almost nobody here reads it.
Does the effect persist with continued dosing or does tolerance develop?