[Meta] proposal — a flair for gastric emptying posts
Proposal, not a decision: proposal — a flair for gastric emptying posts. Went looking for human data on a mechanism everybody here asserts. Found preclinical work and one small study. That was clarifying. Tried to build a mental model from mechanism alone and produced a confident prediction that the trial data flatly…
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.
Correction: that is glucose-dependent insulin secretion, which is why hypoglycaemia risk is low as monotherapy. Not the same claim as you made.
Agreed — the incretin effect is the load-bearing concept and everything downstream reads differently once you have it.
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Agreed that receptor distribution is the key to the side-effect map. It is not a mystery, it is anatomy.