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c/glp1science·submitted 2 years ago by u/flair_enthusiast

[Discussion] incretin is doing more work than we give it credit for

Discussionbranch of 8 comments

incretin is doing more work than we give it credit for — a position I have arrived at slowly and would like tested. Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect…

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8 comments, started 2 years ago
u/gastric_emptying_gMOD330 points·2 years ago

Speculation is welcome here if it is labelled. This one has been relabelled rather than removed.

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u/lurker_for_years0 points·2 years ago

Speculation is welcome here if it is labelled.

gastric_emptying_g is right that mechanism gives direction and not magnitude. Worth pinning.

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u/enzo_danquah1 point·2 years ago

half-life is why these are weekly and not daily

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[deleted]1 point·2 years ago

[deleted]

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u/hassan_castellanos1 point·2 years ago

a mechanism you can state is not a mechanism you have demonstrated

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u/milos_vanhecke1 point·2 years ago

GIP is the arm people argue about because the biology is genuinely unsettled

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u/niels_roos109 points·2 years ago

Agreed — the incretin effect is the load-bearing concept and everything downstream reads differently once you have it.

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