three years of mechanism threads, summarised so you do not have to read them
three years of mechanism threads, summarised so you do not have to read them, and I am aware this is a minority view on this board. The mental model, in four steps, that makes the rest of this site legible. One: gut hormones amplify the insulin response to food. Two: agonists at those receptors act peripherally on…
Left up and flaired Explainer. This is the standard of post the board was created for.
Agreed that receptor distribution is the key to the side-effect map. It is not a mystery, it is anatomy.
Correction: that is glucose-dependent insulin secretion, which is why hypoglycaemia risk is low as monotherapy. Not the same claim as you made.
Asked a question here that I thought was stupid and got three papers back. Best thread I have been in on this site.
What does the discussion section say about the limitation you are glossing?
The incretin effect is the observation that oral glucose provokes a larger insulin response than intravenous glucose at matched glycaemia, and the difference is mediated by gut hormones. That is the foundation the whole class sits on.