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c/glp1science·submitted 1 months ago by u/lurker_for_years

[Meta] proposal — a flair for receptor posts

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proposal — a flair for receptor posts, and it will stay as it is unless somebody makes the case to change it. The mental model, in four steps, that makes the rest of this site legible. One: gut hormones amplify the insulin response to food. Two: agonists at those receptors act peripherally on insulin secretion and…

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6 comments, started 1 months ago
u/santiago_rasmussen82 points·1 months ago

Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.

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u/neha_krastev26 points·1 months ago·edited

Are we talking about receptor affinity or clinical potency?

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u/split_dose_sceptic8 points·1 months ago

glucagon agonism sounds paradoxical until you read the energy expenditure work

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[removed]6 points·1 months ago

[removed by moderator]

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u/the_poster_in_question_20269 points·1 months ago

Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.

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u/gradient_goblin61 points·1 months ago

Cosigning on GIP. The genuinely interesting thing is that the biology is not settled and the clinical result is nonetheless robust.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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