why does GIP agonism seem to reduce nausea rather than add to it
Asking properly rather than in a comment on somebody else’s thread: why does GIP agonism seem to reduce nausea rather than add to it. Why mechanism talk keeps misleading people, including me. A mechanism tells you a direction. It does not tell you a magnitude, a timescale, or whether the pathway is operative at the…
Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally.
Right — mechanism gives you a direction. It never gives you an effect size and people use it as though it does.
What does the discussion section say about the limitation you are glossing?
Yes. The discussion section is where the authors say what they actually think, and almost nobody here reads it.
Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random.
a mechanism you can state is not a mechanism you have demonstrated