GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
637
c/glp1muscle·posted 2 months ago by u/milos_vestergaard

how much of what we believe about DEXA actually comes from sarcopenia threads

Question Clean Column ×3

Question in the title, detail here: how much of what we believe about DEXA actually comes from sarcopenia threads.

Some lean mass loss accompanies weight loss in any deficit. Resistance training and adequate protein intake are the two interventions with the best evidence for limiting the proportion.

Fat-free mass index is a ratio of fat-free mass to height squared. It moves when either term does, which makes it awkward to interpret during active weight change.

Hydration status and fasting state affect the lean mass estimate. Standardising both is the difference between a comparison and a coin toss.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

707 up / 70 down91% upvoted23 commentsid 111cgc10 May 2026

23 comments

22 in this archive, depth 5

best — the order this archive was captured in

u/oskar_kaufmann69 points·2 months ago·edited

Nothing here is a training or nutrition prescription. Targets and programmes are matters for somebody who knows your history and your training background.

replysharereportpermalink
u/zaid_roos59 points·2 months ago

Not convinced by that DEXA comparison. Different machine, different protocol, and the difference is inside the error.

replysharereportpermalink
u/ferran_dahlberg15 points·2 months ago

Resistance training, and at what frequency?

replysharereportpermalink
u/lift_heavy_thingsresistance training45 points·2 months ago

Reduced appetite makes hitting a protein target a logistics problem rather than a motivation problem, which is why the practical advice here is about timing and food choice rather than willpower.

replysharereportpermalink
[deleted]32 points·2 months ago

[deleted]

replysharereportpermalink
u/milos_vestergaardOP24 points·2 months ago

Same DEXA machine both times?

replysharereportpermalink
u/vito_chowdhury6 points·2 months ago·edited

How many weeks between the two scans?

replysharereportpermalink
u/lift_heavy_thingsMOD46 points·2 months ago

Left up. Same machine, stated conditions, honest about the error margin.

replysharereportpermalink
u/rina_bergstrom-33 points·2 months ago

DEXA has a meaningful coefficient of variation, and it differs between machines and protocols. Comparing scans from different clinics adds a systematic offset that is invisible on the report.

replysharereportpermalink
u/rasmus_petrescu-49 points·2 months ago

Strength retention is an imperfect but free longitudinal proxy: it is affected by neural factors and by being in a deficit, so it tracks tissue change loosely rather than exactly.

replysharereportpermalink
u/vito_chowdhury-71 points·2 months ago

Protein was the whole problem. Appetite dropped and I was eating well under target without noticing for a month.

replysharereportpermalink
u/stubborn_batchlist_pls1 point·2 months ago

Strength retention is an imperfect but free longitudinal proxy: it is affected by neural factors and by being in a deficit, so it tracks tissue change

This is the whole intervention. Protein and resistance training.

replysharereportpermalink
u/milos_vestergaard1 point·2 months ago

Started weighing protein rather than estimating it. The gap between what I thought and what I ate was embarrassing.

replysharereportpermalink
u/adaeze_cabrera29 points·2 months ago

lean mass loss during weight loss is expected, the question is how much

replysharereportpermalink
u/soren_yildiz8 points·2 months ago

Same. Volume over novelty. Changing programme every six weeks cost me a year.

replysharereportpermalink
u/milos_vestergaard5 points·2 months ago·edited

That protein figure is grams per day, not grams per kilogram. Different claim entirely.

replysharereportpermalink
u/protein_first_pnutrition3 points·2 months ago

Have the lifts held, dropped, or moved around?

replysharereportpermalink
u/rasmus_petrescu2 points·2 months ago

nothing on this board is a training or nutrition prescription

replysharereportpermalink
u/milos_vestergaardOP1 point·2 months ago

losing weight slower does not automatically preserve more lean mass

replysharereportpermalink
u/milos_vestergaardOP1 point·2 months ago

Correction: those scans are from different machines, and the difference you are describing is within the measurement error.

replysharereportpermalink
u/line_demir1 point·2 months ago

Three scans over eighteen months, same machine, same conditions. Only the third one made the first two interpretable.

replysharereportpermalink
u/trialwatch_theotrial nerd2 points·2 months ago

do not compare your composition to a trial average

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/glp1muscle

Lean-mass retention during rapid weight loss: protein targets, resistance-training minimums, DEXA and BIA measurement reality, FFMI tracking, and the sarcopenia question that nobody funded a proper trial for.

30kmembers
62submissions
Jun 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
c/glp1muscle rules
  1. Body-composition claims need a method. Bathroom BIA scales are not a method.
  2. Protein targets in g/kg, not "lots".
  3. No supplement selling, no coaching solicitation.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.