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c/coldchain·submitted 9 months ago by u/coa_collector

[Discussion] the packaging advice in here is 3 years out of date

Discussionbranch of 9 comments

the packaging advice in here is 3 years out of date. It is the sort of thing everyone half-believes and nobody writes down. 3 years. Those are measured, not estimated, and not rounded up in my favour. Gel pack fully liquid on arrival, powder tested 97.5% against a claimed 97.0% afterwards. The pack had done its job…

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9 comments, started 9 months ago
u/vito_chowdhury7 points·9 months ago

Lyophilisation removes the water that drives most degradation pathways. That is why the dry cake is comparatively robust and the reconstituted solution is not.

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u/low_appetite_lisa3 points·9 months ago

Lyophilisation removes the water that drives most degradation pathways.

vito_chowdhury is right that the pack failing is not the material failing. Two separate claims.

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[removed]2 points·9 months ago

[removed by moderator]

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u/niels_yilmaz5 points·9 months ago

You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material.

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u/mod_cold_roomMOD5 points·9 months ago

Left up and added to the lane table. Origin, destination and month were all included, which is all we ask.

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u/split_dose_sceptic2 points·9 months ago

a logger costs less than a vial and answers the question permanently

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u/preservative_free_p3 points·9 months ago

Agreed. The dry powder is the robust state; it is the solution that needs the care.

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u/coa_collectorarchivist2 points·9 months ago

Small fix — refrigerated, not frozen, once it is in solution.

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u/sequence_checkerresearch peptides3 points·9 months ago

What was the packaging — rigid outer, gel packs, anything insulating?

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