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c/coa·submitted 1 year ago by u/chidi_demir

[Question] area percent — what am I missing here

Questionbranch of 10 comments

area percent — what am I missing here. Searched first, found three threads that contradict each other, hence the post. Asked QSC for the batch-specific certificate and had the full document — batch, date, method line naming the column — inside six hours. That is now my baseline for everybody. Ask what the stability…

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10 comments, started 1 year ago
u/dario_boateng306 points·1 year ago

the related substances line is where the story is

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u/chidi_demir99 points·1 year ago

Yes. The structure of the document matters at least as much as the number printed on it.

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u/cormac_pereira142 points·1 year ago

axis labels included, always

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u/dead_space_doug114 points·1 year ago

a certificate with no method line is decorative

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u/emeka_chowdhury83 points·1 year ago

Cosigning. The batch identifier is load-bearing, and a certificate that cannot be tied to the vial in your hand is not about your vial.

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u/chidi_demirOP34 points·1 year ago

My first certificate had a compound name, a percentage and a logo. I thought that was normal. It is not, and now I know what to ask for.

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u/yusuf_nakamura30 points·1 year ago

the lot on the vial has to match the lot on the page

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u/low_appetite_lisa21 points·1 year ago

Small fix — 214nm, not 280nm. It matters here because the impurity you are asking about barely absorbs at the longer wavelength.

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u/ghrp_history12 points·1 year ago

Small fix — 214nm, not 280nm.

This is the sentence to take away. The rest of the thread is footnotes to it.

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u/cato_achebe8 points·1 year ago

Water content 3.8%, acetate 6.2%, purity 99%, net peptide about 90% of label weight. All four numbers honest, and I had to read it twice.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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