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c/coa·submitted 13 days ago by u/halima_boateng

[COA] what does "related substances 1.4%" actually mean for my vial

COAbranch of 7 comments

Posting this because the title is the whole finding — what does "related substances 1.4%" actually mean for my vial — and a number without its method is a rumour. 1.4%. Those are measured, not estimated, and not rounded up in my favour. Started keeping a folder of every certificate I have been sent. The ones that…

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7 comments, started 13 days ago
u/cesar_ivaturi8 points·13 days ago

Net peptide content is the fraction of the powder that is actually peptide once counterion, water and residual solvent are accounted for. A 99% pure acetate salt can still be about 85% peptide by mass.

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u/elodie_yilmaz4 points·12 days ago

Pushing back a little: a missing field is usually presentation, not concealment. Ask for the full document before drawing conclusions.

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u/soren_nkemelu6 points·13 days ago

The document I was worried about turned out to be a re-issue with a later creation date. Asked, got the original, entirely ordinary.

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u/tove_ogunleye7 points·12 days ago

chromatogram or it did not happen

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u/tidy_vialdrawer_watch284 points·12 days ago·edited

chromatogram or it did not happen

Agreed, and the practical version is: ask for the itemised table. If it exists, you get it.

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u/neha_erdogan5 points·12 days ago

post the whole document, not the headline number

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u/halima_boatengOP2 points·12 days ago

My first certificate had a compound name, a percentage and a logo. I thought that was normal. It is not, and now I know what to ask for.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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