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c/coa·submitted 8 months ago by u/amara_halonen

[Vendor] KP vs BCH on the same compound, same month — both cleared 97.5%

Discussionbranch of 7 comments

Posting this because the title is the whole finding — KP vs BCH on the same compound, same month — both cleared 97.5% — and a number without its method is a rumour. 97.5% — those are the numbers, and they are the ones I am willing to defend. Started keeping a folder of every certificate I have been sent. The ones…

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7 comments, started 8 months ago
u/low_appetite_lisa246 points·8 months ago

How to ask for a batch record without it turning into a negotiation.

One email, three requests: the batch-specific certificate for lot X, the method line behind it, and the storage condition the stability statement was written against. No preamble, no explanation of why you want it.

What comes back is the signal. A full document with the column and gradient printed on it, inside a day, tells you there is a real quality system behind the operation. That is the test I run before I order from anyone new, and it costs nothing.

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u/mikkel_correia200 points·8 months ago

the related substances line is where the story is

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u/freya_baptista157 points·8 months ago

Same view. ERP prints the column and the gradient, which means somebody could actually reproduce the run.

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u/gallbladder_gary66 points·8 months ago

UV at 214nm sees the peptide bond and picks up almost everything; at 280nm you are looking at aromatics only. Which wavelength the number came from is part of the number.

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u/amara_halonenOP33 points·8 months ago

Asked CPC for the batch-specific certificate and had the full document — batch, date, method line naming the column — inside six hours. That is now my baseline for everybody.

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[removed]25 points·8 months ago

[removed by moderator]

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u/coa_janitorMOD108 points·8 months ago

Your name and address edited out of the screenshot above. The batch details are untouched and should stay.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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