[Results] 38 weeks, 6kg, and satiety was the hard part
38 weeks, 6kg, and satiety was the hard part. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else. Pulling the figures out of the title: 38 weeks and 6kg. All of it is written down as it happened rather than reconstructed. The tolerability tables were more…
Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two.
Which trial and which readout?
Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.
Monotherapy arm or combination arm?
Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same receptor.
Cosigning on the thin independent data. Fewer members test this, so the bands are wider and should be treated that way.
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Correcting myself upthread: I gave the 94-week figure and the paper reports 45 weeks.
satiety signalling rather than incretin signalling