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c/cagrilintide·submitted 1 year ago by u/sten_rautio

[PSA] cagrilintide is not what most of this community thinks it is

Trial Databranch of 6 comments

Writing this once so it can be linked instead of retyped: cagrilintide is not what most of this community thinks it is. Nothing containing this compound is approved as a standalone product, and research-use-only material is not approved for human use. Dosing intuitions from the GLP-1 boards do not transfer. Different…

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6 comments, started 1 year ago
u/nl_verzekering87 points·1 year ago

Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two.

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u/amylin_amyMOD64 points·1 year ago

Left up. Thin evidence base, honestly labelled, which is the standard here.

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u/marta_ilunga50 points·1 year ago

I would not extrapolate the tolerability profile from the monotherapy arm to the combination. The trials report them separately for a reason.

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u/tomas_kimani12 points·1 year ago

Went looking for independent results on this and found a handful across the whole site. That is the honest state of the evidence.

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u/incretin_ivypharmacology3 points·1 year ago

Kept a log purely because so few people are logging this one. It is one person and it is not data.

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u/plain_titration38 points·1 year ago

Is there any independent purity data on this compound that you have seen?

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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