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c/bpc157·submitted 1 year ago by u/isabela_nilsen

why does nobody talk about tendon

Scepticbranch of 17 comments

The title is the whole question — why does nobody talk about tendon — but here is why I am asking. Kept a reconstituted vial too long out of curiosity and learned something about solution stability I would rather have read. Assumed regulatory status was static and it was not. Checked again this year and the answer…

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17 comments, started 1 year ago
u/enzo_ferrari85 points·1 year ago

The published literature is overwhelmingly preclinical, largely in rodent models. Translating a rodent result into a human expectation is not a small step, and almost every confident claim here takes it silently.

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u/neha_rahimi124 points·1 year ago

Ask for the theoretical mass alongside the measured one. It is a one-line addition to a certificate and it converts a purity claim into an identity claim.

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[removed]90 points·1 year ago

[removed by moderator]

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u/ice_pack_auditcold chain69 points·1 year ago

Regulatory classification differs between jurisdictions and has changed in several of them recently. Any answer to a status question needs a place and a date attached.

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u/endotoxin_elliemicro55 points·1 year ago

pentadecapeptide, fifteen residues, and the sequence is public

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u/neha_rahimi64 points·1 year ago

Cosigning that the papers are more modest than the summaries of them. That is true across this whole site and especially here.

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u/isabela_nilsenOP25 points·1 year ago

Was there identity confirmation, or only a purity figure?

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u/ismael_chukwu26 points·1 year ago

identity testing matters more here than purity does

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u/ruben_cabrera0 points·1 year ago

The published literature is overwhelmingly preclinical, largely in rodent models.

Adding the standing caveat — research material is not approved for human use, wherever you are.

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u/enzo_ferrari27 points·1 year ago

Correction: that study was in rodents. Worth stating explicitly since the thread has been reading it as clinical.

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u/pavel_kimani8 points·1 year ago

Reconstituted or powder, and how long has it been in solution?

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u/bruno_dumitru31 points·1 year ago

I would not extrapolate a mechanism from a model system to a person in one step, which is what that comment does.

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u/marta_ilunga-16 points·1 year ago

short peptides are cheap, which cuts both ways

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u/hamza_weiss1 point·1 year ago

That claim traces back to a single preclinical paper that says something considerably narrower.

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u/rosa_almeida25 points·1 year ago

preclinical enthusiasm is not clinical evidence

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u/bence_ibarra13 points·1 year ago

Small fix — fifteen residues, not seventeen. The sequence is public and easy to check.

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u/throwaway_918219 points·1 year ago

the tendon claims are the most repeated and the least evidenced

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About c/bpc157

BPC-157 as it actually is: a pentadecapeptide with a genuinely interesting rodent tendon-and-gut literature, near-zero controlled human data, a naming and sequence mess in the supply chain, and a regulatory status that changed sharply in several countries.

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