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u/reflux_report

GERD got worse before it got better. Smaller meals, earlier dinner.

member · joined 21 Jul 2024

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Comments — page 2 of 3

comment on help me understand retatrutide, I have read the wiki twice in c/retatrutide · 5 points · 4 months ago

a lot of the confident posting here is extrapolation

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comment on three years of dead space threads, summarised so you do not have to read them in c/reconstitution · 152 points · 4 months ago

bacteriostatic water has the preservative, sterile water does not

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comment on small win: protein stopped being a problem at week 41 in c/glp1muscle · 28 points · 5 months ago

Strength retention is an imperfect but free longitudinal proxy: it is affected by neural factors and by being in a deficit, so it tracks tissue change loosely rather than exactly.

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comment on reading network threads from 2024 and half of it aged badly in c/cryptopay · 13 points · 5 months ago

Sent a test amount first on a large order. Cost me a fraction of a percent and I have done it every time since.

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comment on area percent — 13 things I got wrong before I got it right in c/coa · 1 points · 5 months ago

Are the related substances itemised or is it a single total?

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comment on help me understand triple agonist, I have read the wiki twice in c/retatrutide · 65 points · 5 months ago

What is the source for that figure — the published paper or a summary of it?

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comment on unpopular opinion: most of what gets said here about COA is guesswork in c/coa · 254 points · 5 months ago

the related substances line is where the story is

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comment on help me understand lean mass, I have read the wiki twice in c/glp1muscle · 10 points · 6 months ago

Hydration status and fasting state affect the lean mass estimate. Standardising both is the difference between a comparison and a coin toss.

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comment on [Meta] proposal — a flair for HPLC posts in c/hplc · 32 points · 6 months ago

Area percent is the integrated area of your peak over the total integrated area at one wavelength on one gradient. Change any of those and the number changes without the sample changing.

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comment on is it normal to get fatigue at week 5 in c/retatrutide · 277 points · 6 months ago

Where the evidence actually stands, since every thread here assumes a different answer.

Phase 2 reported a large mean body weight change at 48 weeks across a few hundred participants with a slow, protocol-driven escalation. The effect size was striking. The confidence intervals were wide, the population was small, and the duration was under a year.

Phase 3 is running. Until it reports, everything else — including the ranking arguments this board loves — is extrapolation from a small study. That is not a criticism of the compound; it is a description of the evidence.

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comment on [Question] gradient — what am I missing here in c/hplc · 65 points · 7 months ago

Sent the same vial to VendorInvestigate and Janoshik. 98.1% against a claimed 98.0%. The difference was the gradient, not the material.

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comment on [Question] how do you actually verify escrow in c/cryptopay · 3 points · 7 months ago

Confirmations are the count of blocks built on top of the one containing your transaction. Until there are some, the transaction is not settled in any meaningful sense.

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comment on [Results] 78 weeks, 16kg, and plateau was the hard part in c/semaglutide · 13 points · 7 months ago

What dose and how many weeks at it before this started?

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comment on [Vendor] FGP order #23 — Germany, 12 days, no drama, receipts inside in c/cryptopay · 25 points · 7 months ago

ask which networks they actually accept before you order

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comment on [Lab] MKM cagri — Medutest came back 97.7% against a claimed 97.0% in c/hplc · 100 points · 7 months ago

ghost peak, check the plumbing first, it is always the plumbing

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comment on reading retatrutide threads from 2024 and half of it aged badly in c/retatrutide · 89 points · 8 months ago

Right, and it bears repeating that nothing here is approved anywhere and research material is not for human use.

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comment on why does nobody talk about weekly dosing in c/semaglutide · 1 points · 8 months ago

I would push back gently.

Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.

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comment on [Meta] the mg/mL rule is doing its job and people should stop complaining in c/reconstitution · 123 points · 8 months ago

What concentration did you actually reconstitute at, rather than what did you intend to?

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comment on [Discussion] we are measuring HPLC at the wrong time and calling it noise in c/hplc · 10 points · 8 months ago

This. A shoulder that does not baseline-resolve is a question, not a quantity.

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comment on [Discussion] escrow is doing more work than we give it credit for in c/cryptopay · 0 points · 8 months ago

Small fix — that is the network fee, not a supplier charge. The distinction matters for the complaint you are making.

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comment on [Question] TRIUMPH — what am I missing here in c/retatrutide · 234 points · 9 months ago

comparing reta phase 2 to sema phase 3 is comparing different things

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comment on [Discussion] can we stop arguing about gas fees until somebody posts a number in c/cryptopay · 1 points · 9 months ago

Correcting myself upthread: it was 12 confirmations, not the number I posted, and it settled fine.

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comment on [Discussion] can we stop arguing about gas fees until somebody posts a number in c/cryptopay · 0 points · 9 months ago

How many confirmations does it show?

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comment on [Discussion] can we stop arguing about gas fees until somebody posts a number in c/cryptopay · 2 points · 9 months ago

Which networks did they list as accepted?

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comment on tried food noise for 14 weeks. here is what happened. in c/semaglutide · 174 points · 10 months ago

Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.

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comment on how much of what we believe about HPLC actually comes from integration threads in c/hplc · 1 points · 10 months ago

Cosigning the wavelength point. Half the disagreements in this board are two people looking at different detectors.

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comment on Wegovy: what the trials say vs what this community says in c/semaglutide · 133 points · 10 months ago

Week 32: 7kg down, early fullness basically gone since about week 6, and the honest headline is that nothing dramatic happened. It was boring and it worked.

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comment on [Discussion] the dead space advice in here is 3 years out of date in c/reconstitution · 11 points · 10 months ago

Yes. Writing 10mg/mL on the vial takes four seconds and removes the entire class of error this board exists to fix.

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comment on unpopular opinion: most of what gets said here about dead space is guesswork in c/reconstitution · 2 points · 11 months ago

Not quite. Bacteriostatic and sterile water are not interchangeable for a multi-draw vial, and the difference is the preservative.

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comment on [Discussion] the reconstitution advice in here is 3 years out of date in c/reconstitution · 72 points · 11 months ago

Wrote the date on the vial as well as the concentration after losing track of which one was opened first.

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comment on how much of what we believe about HPLC actually comes from LC-MS threads in c/hplc · 54 points · 11 months ago

The system suitability argument, since it comes up whenever somebody posts a number without one.

Before the sample result means anything, the instrument has to be shown to be fit that day: replicate injections with an acceptable RSD on area, a tailing factor inside limits, adequate plate count, and a resolution check between the pair you care about.

None of that is exotic and all of it is routine in a laboratory that reports for a living. Its absence does not mean a number is wrong; it means the number is unanchored, and unanchored numbers should not be quoted to two decimal places on this board.

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comment on reading purity threads from 2024 and half of it aged badly in c/hplc · 1 points · 12 months ago

Agreed, and it is why TFC printing the column and gradient on the certificate is genuinely useful rather than decorative.

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comment on the TRIUMPH thing finally clicked for me and I want to write it down in c/retatrutide · 19 points · 1 year ago

Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.

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comment on the dead space question that gets asked weekly, answered properly in c/reconstitution · 27 points · 1 year ago

Adding more water does not change how much peptide is in the vial. It changes the concentration, which changes the volume you draw for the same amount. That is the entire relationship.

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comment on purity — 6 things I got wrong before I got it right in c/coa · 174 points · 1 year ago

Yes. The structure of the document matters at least as much as the number printed on it.

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comment on does chargeback actually matter or is it forum lore at this point in c/cryptopay · 13 points · 1 year ago

Escrow is not standard in this space. Wanting it is reasonable; expecting it as default is not.

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comment on does chargeback actually matter or is it forum lore at this point in c/cryptopay · 14 points · 1 year ago

Sent to the right address on the wrong chain years ago. Nothing to be done. That is the lesson I paid for.

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comment on does chargeback actually matter or is it forum lore at this point in c/cryptopay · 28 points · 1 year ago

Memo requirements are chain-specific. The chain you are describing does not use one.

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comment on does method development actually matter or is it forum lore at this point in c/hplc · 62 points · 1 year ago

Started reporting my own integrations with the baseline choice stated. Arguments in my threads dropped by about half.

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comment on three years of weekly dosing threads, summarised so you do not have to read them in c/semaglutide · 29 points · 1 year ago

Yes. Week 54 is when almost everybody writes the "is it still working" post, and almost everybody is fine.

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