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Fragment ions do not care about your marketing copy.

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Comments — page 3 of 3

comment on [Meta] the private prescription rule is doing its job and people should stop complaining in c/glp1uk · 53 points · 1 year ago

Discharge at goal, which nobody warns people about.

Specialist services in England are commissioned to deliver a defined intervention. Reaching goal is a successful outcome and it typically ends with discharge back to primary care. Whether prescribing continues after that is a local decision that varies, and plenty of members here have discovered it at the point of discharge rather than at the start.

The useful thing to do is ask early: what happens when I finish, and does prescribing continue in primary care in this area. Ask it in writing, keep the answer, and you will at least know which conversation you are heading for.

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comment on help me understand lyophilised, I have read the wiki twice in c/coldchain · 22 points · 1 year ago

write the reconstitution date on the vial

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comment on reading co-agonism threads from 2024 and half of it aged badly in c/cagrilintide · 188 points · 1 year ago

That is preclinical work and the thread is treating it as a human finding.

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comment on help me understand lyophilised, I have read the wiki twice in c/coldchain · 27 points · 1 year ago

Which lane, and had it been quoted at that transit time?

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comment on sequence — 10 things I got wrong before I got it right in c/bpc157 · 26 points · 1 year ago

Right, and regulatory status has genuinely moved in several jurisdictions. Answers from three years ago may be wrong now.

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comment on the NHS thing finally clicked for me and I want to write it down in c/glp1uk · 10 points · 1 year ago

That is the first-month offer price, not the ongoing monthly cost. The tracker records the second one.

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comment on CagriSema: the version I wish someone had shown me in week 1 in c/cagrilintide · 72 points · 1 year ago

Correction: that is the combination programme, not the monotherapy readout. Different arms, different numbers.

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comment on [Question] Australia — has anyone got a straight answer on confirmations in c/cryptopay · 1 points · 1 year ago

Right, and confirmations are the status. "Sent" means nothing until the chain agrees.

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comment on genuine question about gas fees that I am slightly embarrassed to ask in c/cryptopay · 260 points · 1 year ago

Escrow is not standard in this space. Wanting it is reasonable; expecting it as default is not.

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comment on [Question] how do you actually verify SURPASS in c/trialwatch · 15 points · 1 year ago

phase 2 finds a dose, phase 3 measures the effect

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comment on does SELECT actually matter or is it forum lore at this point in c/trialwatch · 44 points · 1 year ago

Correction: SURMOUNT is the obesity programme and SURPASS is the diabetes one. The figure you quoted belongs to the other one.

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comment on three years of beginner threads, summarised so you do not have to read them in c/newbiequestions · 41 points · 1 year ago

the first month is a tolerance check, not a results phase

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comment on three years of beginner threads, summarised so you do not have to read them in c/newbiequestions · 50 points · 1 year ago

Is this your first step up or the starting dose?

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comment on help me understand SURMOUNT, I have read the wiki twice in c/trialwatch · -17 points · 1 year ago

Read a press release and the publication three months apart. The hedging in the second one was substantial.

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comment on [Discussion] private prescription is doing more work than we give it credit for in c/glp1uk · 143 points · 1 year ago

Four pharmacies, four prices, same product, same month. The spread was larger than I expected and none of them were the headline offer.

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comment on the first time thing finally clicked for me and I want to write it down in c/newbiequestions · 6 points · 1 year ago

a COA is a certificate of analysis, the lab document for a batch

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comment on [Discussion] the chargeback advice in here is 3 years out of date in c/cryptopay · 11 points · 1 year ago

nobody legitimate needs the payment in the next ten minutes

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comment on dose history — my 20-week log, condensed into one table in c/dosinglogs · 30 points · 1 year ago

Annotation is what makes a log survive contact with your future self. A single note beside an unusual week saves an hour of puzzled reconstruction later.

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comment on hazard ratio is the most under-discussed thing on this board in c/trialwatch · 44 points · 1 year ago

Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.

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comment on [Question] how do you actually verify USDC in c/cryptopay · 34 points · 1 year ago

match the address character by character, or paste and verify

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comment on [Meta] the week one rule is doing its job and people should stop complaining in c/newbiequestions · 10 points · 1 year ago

Bacteriostatic water contains a preservative, which is what makes repeated entry into a vial reasonable. Sterile water does not, and the two are not interchangeable for that purpose.

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comment on [Meta] the regulatory rule is doing its job and people should stop complaining in c/bpc157 · 23 points · 2 years ago

research-use-only means not approved for human use, and here that covers everything

marit_sandvik is right that a pure something-else is still something else.

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comment on [Vendor] JEEP order #6 — Ireland, 13 days, no drama, receipts inside in c/coldchain · 4 points · 2 years ago

Asked ERP which lines they hold regionally and got a straight list back. That answered my summer ordering question completely.

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comment on am I the only one who found amylin harder than the injections in c/cagrilintide · 46 points · 2 years ago

Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same recepto

Disagreeing with this line: that figure is from a combination arm and is being quoted as monotherapy.

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comment on how much of what we believe about weekly update actually comes from tracking threads in c/dosinglogs · 10 points · 2 years ago

Logged the missed weeks as blanks rather than skipping them. The gaps turned out to be the informative part.

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comment on someone explain pentadecapeptide to me like I have not read a paper in years in c/bpc157 · 0 points · 2 years ago

a fifteen-residue peptide is easy to make and easy to make badly

zaid_eriksen is right that a pure something-else is still something else.

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comment on genuine question about TRIUMPH that I am slightly embarrassed to ask in c/trialwatch · 10 points · 2 years ago

That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.

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comment on genuine question about TRIUMPH that I am slightly embarrassed to ask in c/trialwatch · 47 points · 2 years ago

Compared myself to a trial mean for about six months before realising the trial arm had dietitian contact every fortnight.

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comment on small win: what is stopped being a problem at week 72 in c/newbiequestions · 50 points · 2 years ago

Careful — that is a dosing recommendation dressed as an anecdote, and this board removes those.

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comment on [Discussion] can we stop arguing about network until somebody posts a number in c/cryptopay · 79 points · 2 years ago

Same. Asking which networks are accepted before ordering has saved me twice.

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comment on week 68 check-in — 34kg down, nausea manageable, one thing confusing me in c/cagrilintide · 11 points · 2 years ago

do not assume the dosing intuitions from the GLP-1 boards transfer

plain_titration is right that the evidence base here is thin. Conclusions should be held loosely.

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comment on the pricing thing finally clicked for me and I want to write it down in c/glp1uk · 13 points · 2 years ago

Which pharmacy, and what did they quote for the month rather than the first month?

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comment on [Results] 30 weeks on 1.7mg, full numbers, ask me anything boring in c/maintenancephase · 51 points · 2 years ago

maintenance is a phase, not a finish line

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comment on someone explain NHS to me like I have not read a paper in years in c/glp1uk · 100 points · 2 years ago

an online consultation that asks you nothing is not a consultation

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comment on week 17 check-in — 4kg down, fatigue manageable, one thing confusing me in c/cagrilintide · 138 points · 2 years ago

nothing here is approved as a standalone product and research material is not for human use

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comment on Germany: pricing, and what it actually costs here in c/glp1uk · 70 points · 2 years ago

tier 3 waiting lists are measured in years, not months

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comment on unpopular opinion: most of what gets said here about hazard ratio is guesswork in c/trialwatch · 1 points · 2 years ago

read the endpoint before you read the headline

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comment on how much of what we believe about endpoint actually comes from SURMOUNT threads in c/trialwatch · 13 points · 2 years ago

Not convinced. Cross-trial comparison between two programmes with different populations and designs is not a comparison.

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comment on [Meta] the lyophilised rule is doing its job and people should stop complaining in c/coldchain · 1 points · 2 years ago

powder at room temperature for a few days is usually a non-event

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