u/greta_lokken
Contributes reviews on supplier material. Based in Curitiba.
member · joined 13 Apr 2025
Overview — page 3 of 3
comment on someone explain incretin to me like I have not read a paper in years in c/glp1science · 25 points · 2 years ago
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
comment on someone explain Janoshik to me like I have not read a paper in years in c/vendorvetting · 76 points · 2 years ago
Asked GL Biochem for the batch record on a Tuesday and had the full document, batch and method line, before the end of the day. That is the bar now.
comment on 14 months in and titration is still the thing I get wrong in c/semaglutide · 15 points · 2 years ago
Weight change and appetite change are different endpoints on different timescales.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
comment on the mechanism question that gets asked weekly, answered properly in c/glp1science · 2 points · 2 years ago
read the discussion section, that is where the honesty lives
comment on the mechanism question that gets asked weekly, answered properly in c/glp1science · 11 points · 2 years ago
Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a convenience decision.
comment on [Question] how do you actually verify Wegovy in c/semaglutide · 20 points · 2 years ago
This matches me almost exactly, right down to the food noise showing up on the second day and being gone by the fourth.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
comment on [Question] how do you actually verify Wegovy in c/semaglutide · 24 points · 2 years ago
Same. I sat at 1.7mg for three months because it was working and there was nothing to fix.