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u/column_dead_volume

Your ghost peak is plumbing, not product.

member · joined 9 Sep 2024

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comment on peak at 4.2 min, nobody can tell me what it is, ideas in c/hplc · 234 points · 2 days ago

There it is. That is your benzyl alcohol. Redissolve dry powder in mobile phase and the peak will vanish.

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comment on bought a second-hand HPLC. worst best decision of my life. AMA in c/hplc · 121 points · 3 days ago

the crying is the plumbing. it is always the plumbing. every ghost peak i have ever chased was a fitting.

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comment on peak at 4.2 min, nobody can tell me what it is, ideas in c/hplc · 267 points · 3 days ago

4.2 min on that gradient is very early — you are basically still at 20% organic. That is where you find things that barely retain on C18: salts, small polar fragments, excipients, and occasionally the preservative if the vial was reconstituted.

Was it? Because benzyl alcohol elutes early and 0.9% of total area would not be surprising if you injected a reconstituted sample rather than redissolving powder in mobile phase.

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comment on how many independent tests before you trust a vendor. my number is three in c/vendorvetting · 49 points · 8 days ago

the source page log is more useful than the score above it

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comment on [Vendor] JEEP six orders in, zero problems, and i am suspicious of my own luck in c/vendorvetting · 1 points · 18 days ago

reship policy in writing before the order, not after

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comment on why do vendor accounts always have the same three typos in c/vendorvetting · 10 points · 24 days ago

Lead time and minimum quantity are the two facts people forget to ask for and then argue about later. Both are answerable in one email before you commit.

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comment on why do vendor accounts always have the same three typos in c/vendorvetting · 2 points · 25 days ago

Not convinced by the ranking-by-vibe approach here. The community number is derived from reports; your feeling is derived from four posts you remember.

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comment on contraception: the version I wish someone had shown me in week 1 in c/glp1women · 1 points · 26 days ago

ask a clinician about anything involving pregnancy, without exception

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comment on [Results] 60 weeks on 1.0mg, full numbers, ask me anything boring in c/glp1women · 1 points · 1 months ago

That trial did not enrol the population you are asking about, so it cannot answer this.

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comment on group buy organiser vanished with 3.4k. here is the timeline in c/vendorvetting · 58 points · 1 months ago

Started buying small deliberately, tested every lot for the first four, then stopped testing every lot because there was nothing to find.

Would qualify this slightly. Fewer entries means less sampling, and less sampling is not the same as a worse process.

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comment on [Vendor] HJ — small operation, honest about lead times, that is worth something in c/vendorvetting · 71 points · 1 months ago

lead time quoted at checkout is the number to hold them to

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comment on the long term question that gets asked weekly, answered properly in c/maintenancephase · 1 points · 2 months ago

Disagree with chasing the last stretch by going up. You are trading a real side-effect cost for a number you chose arbitrarily.

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comment on the reship question that gets asked weekly, answered properly in c/vendorvetting · 0 points · 3 months ago

the source page log is more useful than the score above it

This is the whole method in one sentence. Everything else in the thread is elaboration.

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comment on reading order records threads from 2024 and half of it aged badly in c/vendorvetting · 60 points · 3 months ago

That is a report count, not a test count. The table lists both and they are very different numbers.

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comment on reading order records threads from 2024 and half of it aged badly in c/vendorvetting · 6 points · 3 months ago

Fixing my own comment above: I said 2 orders and it is 24. The pattern is the same, the count was wrong.

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comment on reading order records threads from 2024 and half of it aged badly in c/vendorvetting · 97 points · 3 months ago

the lot on the vial has to match the lot on the certificate, every time

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comment on 17 months in and PCOS is still the thing I get wrong in c/glp1women · 0 points · 3 months ago

Where in the cycle does this fall, if you are tracking it?

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comment on [Question] how do you actually verify vendor in c/vendorvetting · 64 points · 3 months ago

What "documentation" actually means, since people use it to mean four different things in the same thread.

reads_the_wiki is describing the batch record test and it is the fastest signal available before you spend anything.

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comment on [Meta] proposal — a flair for lowest effective dose posts in c/maintenancephase · 0 points · 4 months ago

What dose are you holding, and for how long now?

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comment on [Meta] proposal — a flair for lowest effective dose posts in c/maintenancephase · 5 points · 4 months ago

What does your weigh-in frequency look like at this point?

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comment on the testing thing finally clicked for me and I want to write it down in c/vendorvetting · 86 points · 4 months ago

Swiss Chems shows up in threads constantly and has almost nothing on file

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comment on the testing thing finally clicked for me and I want to write it down in c/vendorvetting · 30 points · 4 months ago

what does the certificate actually carry — that is the whole question

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comment on [Lab] split one vial across Janoshik and Medutest — 98.1% and 98.9% in c/vendorvetting · 7 points · 4 months ago

lead time quoted at checkout is the number to hold them to

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comment on [Lab] split one vial across Janoshik and Medutest — 98.1% and 98.9% in c/vendorvetting · 77 points · 4 months ago

Yes, and the reason the wider-market table has no scores is that a score built on two reports would be a lie with a decimal point.

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comment on does VendorInvestigate actually matter or is it forum lore at this point in c/vendorvetting · 9 points · 4 months ago

consistency across lots beats one spectacular result

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comment on [Discussion] lowest effective dose is doing more work than we give it credit for in c/maintenancephase · 5 points · 6 months ago

the trials that looked at withdrawal are unambiguous about what follows

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comment on someone explain vendor to me like I have not read a paper in years in c/vendorvetting · 1 points · 7 months ago

I would separate documentation from logistics. A supplier can be excellent at one and ordinary at the other, and averaging them hides it.

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comment on [Discussion] we are measuring dose stretching at the wrong time and calling it noise in c/maintenancephase · 7 points · 8 months ago

Cosigning on planning it in advance. Deciding what maintenance looks like while still losing is much easier than deciding it in a panic.

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comment on genuine question about Medutest that I am slightly embarrassed to ask in c/vendorvetting · 34 points · 9 months ago

the wider-market names in the table are there because nobody has enough data on them

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comment on genuine question about Medutest that I am slightly embarrassed to ask in c/vendorvetting · 166 points · 9 months ago

Same view. A record you can read beats a rating you cannot inspect, every time.

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comment on three years of regain threads, summarised so you do not have to read them in c/maintenancephase · 23 points · 9 months ago

the trials that looked at withdrawal are unambiguous about what follows

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comment on testing is the most under-discussed thing on this board in c/vendorvetting · 196 points · 9 months ago

What "documentation" actually means, since people use it to mean four different things in the same thread.

A certificate of analysis is one document about one lot. A batch record is the manufacturing trail behind that lot. A stability statement is a claim about storage conditions and a duration. A method line is how the number on the certificate was produced.

You can ask for all four. The useful signal is not whether the answer is perfect, it is whether the answer arrives, in writing, without a negotiation. SGN sends the method line unprompted; once you have seen that you stop accepting a bare number from anybody.

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comment on what would you tell week-1 you about contraception in c/glp1women · 43 points · 10 months ago

contraception absorption questions are real and they are worth asking about properly

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comment on [Discussion] can we stop arguing about long term until somebody posts a number in c/maintenancephase · 17 points · 11 months ago

Agreed. Lowest effective dose is the actual maintenance question and it gets almost no airtime next to the escalation threads.

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comment on someone explain fertility to me like I have not read a paper in years in c/glp1women · 14 points · 11 months ago

Cosigning on fertility changing with weight loss. It catches people who were not expecting it at all.

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comment on [Question] how do you actually verify maintenance in c/maintenancephase · 78 points · 11 months ago

This.

Disagreeing with this bit: a two-kilo range is not drift and treating it as a problem creates one.

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comment on [Meta] the PeptideMeter rule is doing its job and people should stop complaining in c/vendorvetting · 1 points · 11 months ago

Minimum order and lead time — did they quote both up front?

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comment on is it normal to get early fullness at week 90 in c/maintenancephase · 1 points · 12 months ago

do not chase the last two kilos with a dose increase

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comment on [PSA] vendor is not what most of this community thinks it is in c/vendorvetting · 380 points · 1 year ago

the wider-market names in the table are there because nobody has enough data on them

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comment on [Discussion] the vendor advice in here is 3 years out of date in c/vendorvetting · 218 points · 1 year ago

Where a supplier holds regional stock, ask which lines are actually held there rather than drop-shipped.

Agreed — and the corollary is that "no data" and "bad data" have to be written differently. The table separates them for exactly that reason.

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