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c/survodutide·submitted 21 days ago by u/yannick_petrov

am I the only one who found hepatic fat harder than the injections

Cautionbranch of 9 comments

The title is the whole question — am I the only one who found hepatic fat harder than the injections — but here is why I am asking. Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost nothing. Nothing containing this…

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9 comments, started 21 days ago
u/kaia_cabrera41 points·21 days ago

Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.

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u/heart_rate_bump9 points·20 days ago

Imaging-derived liver fat fraction is a surrogate.

Agreed — and the endpoint definitions are where the actual claim lives.

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u/rania_marchand3 points·20 days ago

the weight numbers are secondary to what this is being developed for

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u/refund_ledger7 points·20 days ago

Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.

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u/lyophile_lou2 points·20 days ago

Has anyone posted an independent purity result for this compound?

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u/dario_boateng26 points·21 days ago

MASH endpoints are histological, which is a much harder bar

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u/yannick_petrovOP13 points·20 days ago

Which phase and which arm are you quoting?

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u/hub_opssite staff3 points·20 days ago·edited

Phase 2 in a biopsy-confirmed population is a demanding design: recruitment is slow, the population is specific, and the results do not generalise to people who have not been characterised that way.

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u/yannick_petrovOP14 points·20 days ago

the hepatic data is what makes this compound different from the others

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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