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c/researchpeptides·submitted 1 year ago by u/anders_osei

[Discussion] we are measuring research peptides at the wrong time and calling it noise

Discussionbranch of 12 comments

we are measuring research peptides at the wrong time and calling it noise, and I am aware this is a minority view on this board. Asked WXT which lines they keep in regional stock versus make to order and got a clear split. It changed what I ordered. Sent an unusual compound to Medutest because nobody on this site had…

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12 comments, started 1 year ago
u/tb500_tangent80 points·1 year ago

Why purity and net content diverge, and why that is usually honest.

Purity by area percent is a relative measure of what the detector saw. Net peptide content subtracts counterion, water and residual solvent from the powder mass. For some compounds in this catalogue the gap between the two is large.

A vial can therefore be 99% pure and contain considerably less peptide by mass than the label weight suggests, with nothing wrong anywhere. The problem is not the chemistry; it is that people compare a purity figure from one supplier with a net content figure from another and conclude something about both. Ask which number you are being shown, every time.

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u/hplc_hobbyistruns their own column53 points·1 year ago

What lead time were you quoted for that line?

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u/yusuf_achebe36 points·1 year ago·edited

Push back: handling advice from one compound does not transfer to another just because both are peptides.

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u/anders_oseiOP0 points·1 year ago

That method was developed for a different compound class and would not resolve the impurities you are asking about.

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u/rekha_mbeki19 points·1 year ago

Agreed — identity first for anything off the well-travelled list. The purity number is meaningless until you know what it is pure of.

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u/greta_lokken11 points·1 year ago

Correction: that name covers two different molecules and the thread has been discussing both as one.

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u/ignacio_roos7 points·1 year ago

Yes. Nothing in this catalogue is approved for human use and the board should keep saying so.

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u/enzo_danquah4 points·1 year ago

Yes.

ignacio_roos is right that a purity figure without a method is not comparable to one with a method.

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[deleted]2 points·1 year ago

[deleted]

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u/old_account_202365 points·1 year ago

Ordered under a name that turned out to cover two different molecules. Nobody’s fault but mine for not asking.

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u/phase_two_pete16 points·1 year ago

if nobody has tested it here, that is a fact about us, not the compound

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u/sigrid_kaufmann36 points·1 year ago

Small fix — that is net peptide content, not purity. Both are on the certificate and they differ substantially here.

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The wider research-peptide catalogue: thymosin fragments, GH secretagogues, melanocortin agonists, and the long tail of three-letter analogs. Focus on identity verification, handling and the state of the evidence — not on protocols, because these are not approved for human use.

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