[Question] non-peptide — what am I missing here
Trying to get a straight answer on this: non-peptide — what am I missing here. What is actually known, and what is being assumed. Known: it is a small-molecule GLP-1 receptor agonist, dosed daily, with clinical programmes reporting in both obesity and type 2 diabetes. Its tolerability profile broadly resembles the…
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
Read both programme names carefully after mixing them up in a comment and being politely corrected.
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The no-timing-restriction thing is the part I would care about most in practice, and it barely gets mentioned here.
oral semaglutide is a peptide with an absorption enhancer, this is not that
Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.
Adding the standing caveat — unapproved, and research material is not for human use.
Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.
Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.
oral and non-peptide is the whole engineering story
nothing containing this is approved anywhere yet
Which programme and which readout are you quoting?