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c/orforglipron·submitted 1 year ago by u/search_before_post

how much of what we believe about ACHIEVE actually comes from ATTAIN threads

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how much of what we believe about ACHIEVE actually comes from ATTAIN threads. I would rather ask a basic question now than get this wrong quietly for two months. Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can…

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6 comments, started 1 year ago
u/trialwatch_theotrial nerd8 points·1 year ago

The analytical point, which this board keeps getting wrong by importing habits from the peptide side.

For a peptide, purity is typically reported as area percent by HPLC with identity by mass spectrometry, and the impurity classes are things like deletion and oxidation products. For a small molecule the relevant impurities are synthetic intermediates, degradants and residual solvents, and identity is established differently.

So the certificate you would want looks different, the questions to ask are different, and a "purity" figure quoted here is not comparable to one quoted on the peptide boards. Anybody posting a result should say what method produced it, which is good practice everywhere and essential here.

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u/trialwatch_theoMOD5 points·1 year ago

Retitled to name the programme. It is what makes these threads findable in a year.

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u/search_before_postOP3 points·1 year ago

no food and water restrictions is the practical difference people care about

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u/search_before_postOP-17 points·1 year ago

The analytical point, which this board keeps getting wrong by importing habits from the peptide side.

Agreed, and it is why the oral peptide comparison keeps misleading people.

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u/search_before_postOP1 point·1 year ago

Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.

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[removed]6 points·1 year ago

[removed by moderator]

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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