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Single comment threadYou are looking at one branch of three years of oral GLP-1 threads, summarised so you do not have to read them — 65 comments in the full submission. View in context.
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c/orforglipron·submitted 1 year ago by u/freya_marchand

three years of oral GLP-1 threads, summarised so you do not have to read them

Questionbranch of 9 comments

three years of oral GLP-1 threads, summarised so you do not have to read them. Change my mind, genuinely — I have no stake in being right about this. Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.…

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9 comments, started 1 year ago
u/nils_ferreira69 points·1 year ago

Not convinced. Oral semaglutide is a peptide formulated with an absorption enhancer; the comparison you are making does not hold.

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u/incretin_ivypharmacology57 points·1 year ago

Not convinced.

This is the fact the whole board hangs on. Small molecule, not peptide.

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u/paloma_stanescu16 points·1 year ago

This is the fact the whole board hangs on.

Agreed, and it is why the oral peptide comparison keeps misleading people.

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u/ice_pack_auditcold chain-26 points·1 year ago

Are you comparing doses across a small molecule and a peptide?

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u/ravi_sandvik38 points·1 year ago

Small fix — the two programme names got swapped upthread and it changes which population the figure came from.

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u/freya_marchandOP33 points·1 year ago

Phase 2 or phase 3?

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u/deleted_my_history9 points·1 year ago

small molecule, not a peptide, and that changes everything about it

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u/joaquin_trevino10 points·1 year ago

daily dosing changes adherence in both directions

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[deleted]4 points·1 year ago

[deleted]

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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