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c/orforglipron·submitted 2 months ago by u/dario_boateng

12 months in and orforglipron is still the thing I get wrong

Discussionbranch of 7 comments

Here it is: 12 months in and orforglipron is still the thing I get wrong. One person, one log, no control group, so read it accordingly. The relevant figures are 12 months, and they come from the same log I have kept the whole time. Milligram comparisons across molecule classes are meaningless. Potency is a property…

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7 comments, started 2 months ago
u/kenji_kimani38 points·2 months ago

Careful — purity methods for peptides do not read across to a small molecule and the numbers are not equivalent.

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u/phase_two_peteMOD19 points·2 months ago

Left up. It is careful about what is peptide and what is not, which is more than most threads here manage.

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u/anders_karlsen21 points·2 months ago

Left up.

This is the fact the whole board hangs on. Small molecule, not peptide.

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u/hsa_math-17 points·2 months ago

Phase 2 or phase 3?

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u/brigade_detector1 point·2 months ago

do not assume reconstitution intuitions apply, there is nothing to reconstitute

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u/ewan_hovland16 points·2 months ago

Daily dosing gives a very different exposure profile from a weekly injectable: peaks and troughs within each day rather than a smoothed weekly curve.

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u/jonas_cardoso26 points·2 months ago

Went looking for independent testing on this and found essentially nothing, which was clarifying.

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