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c/glp1women·posted 5 months ago by u/step_therapy_s

tried insulin resistance for 13 weeks. here is what happened.

Question Long Haul ×8

tried insulin resistance for 13 weeks. here is what happened, which sounds obvious until you try to state the evidence for it.

Since the title puts numbers in the shop window: 13 weeks.

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

The same dose genuinely feels different at different points in the month for me. Took a year to notice and it was in the log the whole time.

Happy to answer the boring questions. Those are usually the ones worth asking.

419 up / 135 down76% upvoted26 commentsid 3kf7sl27 Feb 2026

26 comments

19 in this archive, depth 6

best — the order this archive was captured in

u/pavel_kravchenko-26 points·5 months ago

Telogen shedding follows a period of significant weight change rather than a specific compound, and it resolves.

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u/katrin_diallo29 points·5 months ago

say what you are actually asking, the vocabulary here is imprecise

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[deleted]11 points·5 months ago

[deleted]

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u/careful_gradient4 points·5 months ago

the research gap is real and it is not your imagination

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u/blunt_coldbox_notes1 point·5 months ago

the same dose can feel different at different points in the month

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u/dilara_szabo24 points·5 months ago

symptom patterns can track the cycle rather than the dose

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u/step_therapy_sOP19 points·5 months ago

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

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u/dilara_szabo15 points·5 months ago

ask a clinician about anything involving pregnancy, without exception

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u/ferran_laurent11 points·5 months ago

Small fix — insulin resistance is a feature commonly seen in PCOS, not a synonym for it.

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u/kian_solberg3 points·5 months ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/honest_syringe_20252 points·5 months ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

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u/dose_creep_dan20 points·5 months ago

Are you asking about the compound, the weight loss, or both?

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u/step_therapy_sOP10 points·5 months ago

Correcting myself upthread: the shedding started at week 15 for me, not the week I gave.

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u/jonas_cardoso3 points·5 months ago

iron and ferritin questions come up here more than anywhere else on the site

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u/lipid_panel_larrybloodwork1 point·5 months ago

perimenopause and this overlap in ways nobody has good data on

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u/dose_creep_dan1 point·5 months ago

Disagree — that is a general claim about absorption and the specific question needs a pharmacist rather than a board.

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u/nora_oyelaran16 points·5 months ago

log the cycle alongside the dose if you want the pattern to be visible

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u/step_therapy_sOP6 points·5 months ago

Asked a pharmacist about the absorption question rather than the internet. Ten minutes, clear answer, done.

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u/mateusz_achebe2 points·5 months ago·edited

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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