[Discussion] the trials under-powered every question in this community
the trials under-powered every question in this community — a position I have arrived at slowly and would like tested.
Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.
Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.
Anything involving pregnancy, contraception efficacy or fertility planning belongs with a clinician. That is not a disclaimer, it is where the answers actually are.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
Left up. It is precise about diagnosis versus finding, which makes the answers usable.
Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.
Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.
perimenopause and this overlap in ways nobody has good data on
perimenopause and this overlap in ways nobody has good data on
Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.
Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.
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ask a clinician about anything involving pregnancy, without exception
That is a general statement about gastric emptying, and the question was about a specific product.
nothing on this board is a substitute for someone who knows your history
Correction: that trial did not enrol the population being discussed, so it cannot support the claim.
Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps so heavily with this board. A diagnosis and a finding are still different things and the distinction matters for what the evidence says.
- 1Fertility can change with weight loss and improved insulin sensitivity. That…6 comments in this branch · started by u/careful_gradient