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c/coldchain·submitted 21 days ago by u/ines_lindqvist

freezing reconstituted product: why the answer is no

Databranch of 8 comments

freezing reconstituted product: why the answer is no. Not a hot take, just something I have not seen said plainly here. Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice…

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8 comments, started 20 days ago
u/ice_pack_auditMOD42 points·20 days ago

Merged into the seasonal thread for that lane so the reports sit together.

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u/noor_cardoso-3 points·20 days ago

a summer lane and a winter lane are different lanes

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u/nadia_kjaer14 points·20 days ago

Yes — reconstitution date on the vial. It is the number you will want and cannot reconstruct.

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u/usb_logger_ursula17 points·19 days ago

Gel pack fully liquid on arrival, powder tested 97.8% against a claimed 97.0% afterwards. The pack had done its job for as long as it was designed to.

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u/nadia_kjaer20 points·19 days ago

light matters more than people think for some of these

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u/noor_cardoso10 points·19 days ago

Where in the fridge is it sitting now?

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u/ireland_drugs_pay15 points·18 days ago

regional stock removes most of this problem entirely

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u/chidi_abubakar22 points·20 days ago

Careful. "The cold chain failed" is a strong claim and the evidence you have is a warm box.

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