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c/coldchain·posted 1 year ago by u/elodie_kuipers

three years of excursion threads, summarised so you do not have to read them

Question Long Haul ×4 Cold Box ×3

The title is the argument: three years of excursion threads, summarised so you do not have to read them. Here is the rest of it.

You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material.

Regional stock changes the question rather than answering it: shorter lanes mean less exposure and fewer variables, which is why the warehouse question is worth asking before ordering in summer.

A transit temperature logger records a distribution, and time above a threshold matters as much as peak temperature. That is the argument for logging rather than guessing.

Happy to answer the boring questions. Those are usually the ones worth asking.

1,521 up / 313 down83% upvoted33 commentsid qd45e718 Sep 2024

33 comments

3 in this archive, depth 1

best — the order this archive was captured in

u/ines_lindqvist127 points·1 year ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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u/britt_okwuosa-3 points·1 year ago

Powder or already in solution?

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u/sten_palacios46 points·1 year ago·edited

Gel packs are designed for a duty cycle. A liquid pack at the end of a longer-than-expected transit is a pack behaving as specified, not evidence of an excursion in the vial.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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