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c/coldchain·submitted 1 months ago by u/marit_laurent

someone explain lyophilised to me like I have not read a paper in years

Databranch of 8 comments

someone explain lyophilised to me like I have not read a paper in years. If this has been answered properly somewhere, link me and I will delete. Seasonality, which the source-page lane tables show clearly once you look for it. The same origin, destination and carrier can differ by several days between February and…

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8 comments, started 1 months ago
u/britt_okwuosa40 points·1 months ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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u/rohan_steiner19 points·1 months ago·edited

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation.

This is the distinction that resolves most threads here — powder and solution are different problems.

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u/marit_laurentOP28 points·1 months ago

if you want to know, log it, otherwise you are guessing

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u/marit_laurentOP21 points·1 months ago

lyophilised powder is far more forgiving than the panic threads suggest

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u/analog_alphabet15 points·1 months ago

Kept a vial at room temperature for eleven days by accident. Tested it out of guilt. It was fine.

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u/lina_almeida5 points·1 months ago

write the reconstitution date on the vial

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u/fatima_yildiz6 points·1 months ago

Yes — reconstitution date on the vial. It is the number you will want and cannot reconstruct.

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u/anjali_tamm3 points·1 months ago

insulation buys hours, not days

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