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c/coldchain·submitted 6 months ago by u/zeynep_ndiaye

excursion — 20 things I got wrong before I got it right

Discussionbranch of 6 comments

Something I keep coming back to: excursion — 20 things I got wrong before I got it right. A stability statement is only meaningful with its conditions attached: temperature, duration, light exposure, and whether it covers powder or solution. Ask which. Regional stock changes the question rather than answering it:…

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6 comments, started 6 months ago
u/aleksi_eriksen52 points·6 months ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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u/transit_variance27 points·6 months ago

I would not freeze it in solution. That is a different failure mode and a worse one.

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u/adaeze_weiss8 points·6 months ago

insulation buys hours, not days

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u/plain_titration_202417 points·6 months ago

I would not freeze it in solution.

Agreed, and a logger costs less than the vial you are worrying about.

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u/britt_okwuosa12 points·6 months ago

Asked QYB which lines they hold regionally and got a straight list back. That answered my summer ordering question completely.

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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