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c/cagrilintide·submitted 1 months ago by u/incretin_ivy

cagrilintide — 17 things I got wrong before I got it right

Cautionbranch of 6 comments

cagrilintide — 17 things I got wrong before I got it right, which sounds obvious until you try to state the evidence for it. Dosing intuitions from the GLP-1 boards do not transfer. Different receptor family, different exposure-response, and no published schedule for members to reason from. Carried an assumption over…

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6 comments, started 1 months ago
u/signe_grimaldi-24 points·1 months ago

Complementary mechanisms are the rationale for pairing: satiety signalling alongside incretin signalling, rather than more agonism at the same receptor.

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u/viktor_nkemelu1 point·1 months ago

Push back: the evidence base here is thin enough that a confident ranking against the established compounds is not supportable.

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u/incretin_ivyOPpharmacology1 point·1 months ago·edited

phase 3 data will change most of what gets said here

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u/incretin_ivyMOD1 point·1 months ago

Standing reminder: nothing here is approved standalone, research material is not for human use, and no dosing schedules for other members.

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u/liv_dumitru1 point·1 months ago

Careful — that is a dosing intuition carried over from another board and there is no basis for it here.

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u/controversial_only1 point·1 months ago

Yes. Anyone reading this board should hold their conclusions loosely until phase 3 reports.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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