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c/cagrilintide·submitted 1 months ago by u/clara_weiss

amylin — 23 things I got wrong before I got it right

Trial Databranch of 6 comments

amylin — 23 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments. Read the combination paper twice before saying anything here. The monotherapy and combination arms tell genuinely different stories. Sent a vial to Medutest because there was almost nothing on…

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6 comments, started 1 months ago
u/incretin_ivypharmacology145 points·1 months ago

Is there any independent purity data on this compound that you have seen?

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u/hugo_pires91 points·1 months ago

Is there any independent purity data on this compound that you have seen?

incretin_ivy is right that the evidence base here is thin. Conclusions should be held loosely.

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u/controversial_only61 points·1 months ago

That result is preclinical. Worth flagging, since the thread has been reading it as human data.

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u/sequence_checkerresearch peptides23 points·1 months ago

nausea profile in the combination trials is the thing to read carefully

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u/chidi_yilmaz34 points·1 months ago·edited

Asked a question here that turned out to be based on a mechanism confusion. Three people untangled it patiently.

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u/clara_weissOP25 points·1 months ago

Correcting myself upthread: I gave the 72-week figure and the paper reports 26 weeks.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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