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c/cagrilintide·submitted 1 months ago by u/sulphur_burps_sue

someone explain CagriSema to me like I have not read a paper in years

Labbranch of 6 comments

someone explain CagriSema to me like I have not read a paper in years, and I want the answer with the reasoning attached rather than just the conclusion. Why this compound is not simply another agonist, which is how it gets described everywhere else. Amylin is co-secreted with insulin and signals satiety through its…

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6 comments, started 1 months ago
u/elin_lundgren39 points·1 months ago

That is preclinical work and the thread is treating it as a human finding.

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u/clara_weiss24 points·1 months ago

Agreed that the monotherapy numbers look modest out of context and that the context is the whole story.

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u/sulphur_burps_sueOP19 points·1 months ago

Small fix — amylin analogue, not a GLP-1 analogue. The whole mechanism argument changes on that word.

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u/mateusz_adebayo12 points·1 months ago

Agreed — it is an amylin analogue and importing intuitions from the incretin boards produces confident nonsense.

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u/slow_logbook_notes3014 points·1 months ago

Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two.

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u/aa_analysis_andy20 points·1 months ago

the interesting data is the combination, not the monotherapy

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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